Maintenance: Adjust dose as needed based on serum uric acid levels Initial dose: 600 to 800 mg orally in divided doses ![]() Usual Adult Dose for Hyperuricemia Secondary to ChemotherapyĢ00 to 400 mg/m2/day IV as a single infusion or in equally divided infusions at 6, 8, or 12 hour intervals Use: For the management of patients with signs and symptoms of primary or secondary gout (acute attacks, tophi, joint destruction, uric acid lithiasis, and/or nephropathy). Normal serum urate levels are usually achieved in 1 to 3 weeks.A gradual dose titration is recommended to reduce the possibility of acute gouty attacks.Oral doses in excess of 300 mg/day should be given in divided doses, preferably after meals to minimize gastric irritation.Minimal Effective Dose: 100 to 200 mg per day Average maintenance dose: 400 to 600 mg orally/day in divided doses.Average maintenance dose: 200 to 300 mg orally once a day. ![]() Increase in increments of 100 mg weekly until a serum uric level of 6 mg/dL or less is attained.Calcium Oxalate Calculi with Hyperuricosuriaĭose will vary with the severity of the disease:.Hyperuricemia Secondary to Chemotherapy.
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